antibody

EphA1, NT (EPHA1, EPH, EPHT, EPHT1, Ephrin type-A receptor 1, EPH tyrosine kinase, EPH tyrosine kinase 1, Erythropoietin-producing hepatoma receptor, Tyrosine-protein kinase receptor EPH)

035115

200 ul

polyclonal

domestic rabbit

nonconjugated

EphA1, NT (EPHA1, EPH, EPHT, EPHT1, Ephrin type-A receptor 1, EPH tyrosine kinase, EPH tyrosine kinase 1, Erythropoietin-producing hepatoma receptor, Tyrosine-protein kinase receptor EPH)

rabbit

Pab

Antibodies

200 ul

IgG

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families). Applications: Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry and ELISA. Other applications have not been tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:50-1:100 Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

EPHA1, EPH, EPHT, EPHT1, Ephrin type-A receptor 1, EPH tyrosine kinase, EPH tyrosine kinase 1, Erythropoietin-producing hepatoma receptor, Tyrosine-protein kinase receptor EPH

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 29-60 in the N-terminal region of human EphA1.

Recognizes human EphA1.

Purified by ammonium sulfate precipitation.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by ammonium sulfate precipitation. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 29-60 in the N-terminal region of human EphA1. Specificity: Recognizes human EphA1. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E FC IHC WB

-20°C

1. Hillier, L.W., et al., Nature 424(6945):157-164 (2003). 2. Owshalimpur, D., et al., Mol. Cell. Probes 13(3):169-173 (1999). 3. Hirai, H., et al., Science 238(4834):1717-1720 (1987).

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