CRTC2, NT (CRTC2, TORC2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2) (APC) | US Biological 034247-APC product information

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product summary

company name :

US Biological

product type :

antibody

product name :

CRTC2, NT (CRTC2, TORC2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2) (APC)

catalog :

034247-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

034247-APC

Product wo Prefix :

CRTC2, NT (CRTC2, TORC2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2) (APC)

Host :

rabbit

Product Type :

Pab

Conjugate :

APC

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). Applications: Suitable for use in Western Blot, Immunohistochemistry, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

CRTC2, TORC2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2

Immunogen :

CRTC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-123 amino acids from the N-terminal region of human CRTC2.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: CRTC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-123 amino acids from the N-terminal region of human CRTC2. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FL IHC WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Nakatsu, Y., et al. J. Biol. Chem. 285(43):33018-33027(2010) Kaizuka, T., et al. J. Biol. Chem. 285(26):20109-20116(2010) Lyo, D., et al. Biochem. Biophys. Res. Commun. 396(2):562-565(2010) Lu, M., et al. J. Am. Soc. Nephrol. 21(5):811-818(2010) Roulin, D., et al. Mol. Cancer 9, 57 (2010) :

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/21/034247-APC_1.jpg