COL1A1, CT (COL1A1, Collagen alpha-1(I) chain, Alpha-1 type I collagen)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

COL1A1, CT (COL1A1, Collagen alpha-1(I) chain, Alpha-1 type I collagen)

catalog :

034087

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

034087

Product wo Prefix :

COL1A1, CT (COL1A1, Collagen alpha-1(I) chain, Alpha-1 type I collagen)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]. Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo

Alternate Name :

COL1A1, Collagen alpha-1(I) chain, Alpha-1 type I collagen

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1077-1106 in the C-terminal region of human COL1A1. Species Sequence Homology: rat, bovine, chicken

Specificity :

Recognizes human COL1A1. Species Crossreactivity: mouse

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As Reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1077-1106 in the C-terminal region of human COL1A1. Species Sequence Homology: rat, bovine, chicken Specificity: Recognizes human COL1A1. Species Crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

-20°C

Reference :

1. Blades, H.Z., et al. Bone 47(5):989-994(2010). 2. Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010). 3. Jin, H., et al. Osteoporos Int (2010). 4. Szczesny, G., et al. Arch Orthop Trauma Surg (2010). 5. Cheung, M.S., et al. J. Bone Miner. Res. (2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/8/034087_1.png