CLCF1, NT (CLCF1, BSF3, CLC, NNT1, Cardiotrophin-like cytokine factor 1, B Cell-stimulating factor 3, Novel neurotrophin-1) (AP) | US Biological 033947-AP product information

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product summary

company name :

US Biological

product type :

antibody

product name :

CLCF1, NT (CLCF1, BSF3, CLC, NNT1, Cardiotrophin-like cytokine factor 1, B Cell-stimulating factor 3, Novel neurotrophin-1) (AP)

catalog :

033947-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

human

product information

Catalog Number :

033947-AP

Product wo Prefix :

CLCF1, NT (CLCF1, BSF3, CLC, NNT1, Cardiotrophin-like cytokine factor 1, B Cell-stimulating factor 3, Novel neurotrophin-1) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

CLCF1, BSF3, CLC, NNT1, Cardiotrophin-like cytokine factor 1, B-cell-stimulating factor 3, Novel neurotrophin-1

Immunogen :

CLCF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 45-72 amino acids selected from the N-terminal region of human CLCF1.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: CLCF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 45-72 amino acids selected from the N-terminal region of human CLCF1. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Rousseau, F., et al. J. Biol. Chem. 283(44):30341-30350(2008) Dagoneau, N., et al. Am. J. Hum. Genet. 80(5):966-970(2007) Rousseau, F., et al. Proc. Natl. Acad. Sci. U.S.A. 103(26):10068-10073(2006) Perret, D., et al. J. Biol. Chem. 279(42):43961-43970(2004) Burger, R., et al. Br. J. Haematol. 123(5):869-878(2003)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/26/033947-AP_1.jpg