antibody

CDX2, NT (CDX2, CDX3, Homeobox protein CDX-2, CDX-3, Caudal-type homeobox protein 2) (APC)

033733-APC

200 ul

polyclonal

domestic rabbit

APC

CDX2, NT (CDX2, CDX3, Homeobox protein CDX-2, CDX-3, Caudal-type homeobox protein 2) (APC)

rabbit

Pab

APC

Antibodies

200 ul

IgG

The caudal type homeo box transcription factors 1 (CDX1) and 2 (CDX2) are candidates for directing intestinal development, differentiation, and maintenance of the intestinal phenotype. CDX1 and CDX2 expression is widely present in the human intestinal and colonic mucosae, but not in the gastric mucosa, suggesting a possible role in the terminal differentiation of the intestine. Increased CDX2 expression is associated with chronic atrophic gastritis. Detectable expression of CDX2 precedes expression of CDX1 during the progression of intestinal metaplasia, thus expression of CDX2 may trigger the initiation and development of intestinal metaplasia. Markedly reduced or absent CDX2 expression was noted by immunohistochemistry in 13 of 15 (87%) large cell minimally differentiated carcinomas (LCMDCs), whereas only 1 of the 25 (4%) differentiated adenocarcinomas (DACs) showed reduced CDX2 expression. Thus, a significant decrease in human CDX1 and/or CDX2 expression may be associated with colorectal tumorigenesis. Applications: Suitable for use in Western Blot, Immunohistochemistry, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:50-100 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

CDX2, CDX3, Homeobox protein CDX-2, CDX-3, Caudal-type homeobox protein 2

CDX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8~38 amino acids from the N-terminal region of human CDX2.

Human

Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein G affinity chromatography. Immunogen: CDX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8~38 amino acids from the N-terminal region of human CDX2. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

FL IHC WB

4°C Do Not Freeze

Phillips, R.W., et al., Am. J. Surg. Pathol. 27(11):1442-1447 (2003). Bai, Y.Q., et al., Oncogene 22(39):7942-7949 (2003). Yamamoto, H., et al., Biochem. Biophys. Res. Commun. 300(4):813-818 (2003). Eda, A., et al., J. Gastroenterol. 37(2):94-100 (2002). Moucadel, V., et al., Biochem. Biophys. Res. Commun. 297(3):607-615 (2002).

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