CDKN2B, NT (CDKN2B, MTS2, Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2, p14-INK4b, p15-INK4b) (APC) | US Biological 033712-APC product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

CDKN2B, NT (CDKN2B, MTS2, Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2, p14-INK4b, p15-INK4b) (APC)

catalog :

033712-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

033712-APC

Product wo Prefix :

CDKN2B, NT (CDKN2B, MTS2, Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2, p14-INK4b, p15-INK4b) (APC)

Host :

rabbit

Product Type :

Pab

Conjugate :

APC

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50 Immunofluorescence: 1:10-50 Flow Cytometry: 1:10-50 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

CDKN2B, MTS2, Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2, p14-INK4b, p15-INK4b

Immunogen :

CDKN2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDKN2B.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: CDKN2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDKN2B. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FC FL IF IHC WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Camacho, C.V., et al. Carcinogenesis 31(10):1889-1896(2010) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1867-1872(2010) Heni, M., et al. Diabetes (2010) In press : Roder, C., et al. Childs Nerv Syst (2010) In press :

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/43/033712-APC_1.jpg

Picture4 Text :

CDKN2B Antibody (N-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.