Cdkn2a, ID (Cdkn2a, Cyclin-dependent kinase inhibitor 2A, isoform 3, p19ARF)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Cdkn2a, ID (Cdkn2a, Cyclin-dependent kinase inhibitor 2A, isoform 3, p19ARF)

catalog :

033706

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse

product information

Catalog Number :

033706

Product wo Prefix :

Cdkn2a, ID (Cdkn2a, Cyclin-dependent kinase inhibitor 2A, isoform 3, p19ARF)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

Cdkn2a, Cyclin-dependent kinase inhibitor 2A, isoform 3, p19ARF

Immunogen :

Mouse Cdkn2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the Central region of mouse Cdkn2a.

Specificity :

Mouse

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: mouse Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: Mouse Cdkn2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the Central region of mouse Cdkn2a. Specificity: Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

Nogueira, C., et al. Oncogene 29(47):6222-6232(2010) Fernandez-Diaz, L.C., et al. Development 137(20):3393-3403(2010) Bennecke, M., et al. Cancer Cell 18(2):135-146(2010) Negishi, M., et al. PLoS ONE 5 (8), E12373 (2010) : Ulanet, D.B., et al. PLoS ONE 5 (8), E12454 (2010) :

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/37/033706_1.jpg