Cdkn2a, ID (Cdkn2a, Cyclin-dependent kinase inhibitor 2A, isoform 3, p19ARF) (AP) | US Biological 033706-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Cdkn2a, ID (Cdkn2a, Cyclin-dependent kinase inhibitor 2A, isoform 3, p19ARF) (AP)

catalog :

033706-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

mouse

product information

Catalog Number :

033706-AP

Product wo Prefix :

Cdkn2a, ID (Cdkn2a, Cyclin-dependent kinase inhibitor 2A, isoform 3, p19ARF) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

Cdkn2a, Cyclin-dependent kinase inhibitor 2A, isoform 3, p19ARF

Immunogen :

Mouse Cdkn2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the Central region of mouse Cdkn2a.

Specificity :

Mouse

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: mouse Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: Mouse Cdkn2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the Central region of mouse Cdkn2a. Specificity: Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Nogueira, C., et al. Oncogene 29(47):6222-6232(2010) Fernandez-Diaz, L.C., et al. Development 137(20):3393-3403(2010) Bennecke, M., et al. Cancer Cell 18(2):135-146(2010) Negishi, M., et al. PLoS ONE 5 (8), E12373 (2010) : Ulanet, D.B., et al. PLoS ONE 5 (8), E12454 (2010) :

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/42/033706-AP_1.jpg