CDK8, ID (CDK8, Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

CDK8, ID (CDK8, Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35)

catalog :

033682

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

033682

Product wo Prefix :

CDK8, ID (CDK8, Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. Applications: Suitable for use in Western Blot, Flow Cytometry and ELISA. Other applications have not been tested. Recommended Dilution: Western Blot: 1:1000 Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

CDK8, Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 249-277 in the central region of human CDK8, UniProt Accession #P49336. Species sequence homology: mouse, xenopus, zebrafish

Specificity :

Recognizes human CDK8.

Purity :

Purified by ammonium sulfate precipitation.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by ammonium sulfate precipitation. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 249-277 in the central region of human CDK8, UniProt Accession #P49336. Species sequence homology: mouse, xenopus, zebrafish Specificity: Recognizes human CDK8. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E FC WB

Storage Temperature :

-20°C

Reference :

1. Seo, J.O., et al. Oncol. Rep. 24(1):285-291(2010) 2. Tsutsui, T., et al. Seikagaku 82(3):191-199(2010) 3. Chattopadhyay, I., et al. Mutat. Res. 696(2):130-138(2010) 4. Donner, A.J., et al. Nat. Struct. Mol. Biol. 17(2):194-201(2010) 5. Alarcon, C., et al. Cell 139(4):757-769(2009)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/49/033682_1.png