CD46, CT (CD46, MCP, MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46) (APC) | US Biological 033516-APC product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

CD46, CT (CD46, MCP, MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46) (APC)

catalog :

033516-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

033516-APC

Product wo Prefix :

CD46, CT (CD46, MCP, MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46) (APC)

Host :

rabbit

Product Type :

Pab

Conjugate :

APC

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

CD46 is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human Herpes virus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:50-100 Flow Cytometry: 1:10-50 Immunofluorescence: 1:10-50 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

CD46, MCP, MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 317-343 in the C-terminal region of human CD46, UniProt Accession #P15529.

Specificity :

Recognizes human CD46.

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As Reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 317-343 in the C-terminal region of human CD46, UniProt Accession #P15529. Specificity: Recognizes human CD46. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FC FL IF IHC WB

Storage Temperature :

4°C Do Not Freeze

Reference :

1. Weyand, N.J., et al. J. Immunol. 184(2):694-701(2010). 2. Santiago, C., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 1), 91-94 (2010). 3. Sullivan, M., et al. Ann. Hum. Genet. 74(1):17-26(2010). 4. Lee, S.W., et al. J. Cell Biol. 156(6):951-957(2002)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/9/033516-APC_1.jpg

Picture4 Text :

Confocal immunofluorescent analysis of 033516 with Hela cell followed by Alexa Fluor® 489-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).