antibody

CD31, CT (Pecam1, Pecam, Pecam-1, Platelet endothelial cell adhesion molecule, CD31) (AP)

033493-AP

200 ul

polyclonal

domestic rabbit

AP

CD31, CT (Pecam1, Pecam, Pecam-1, Platelet endothelial cell adhesion molecule, CD31) (AP)

rabbit

Pab

AP

Antibodies

200 ul

IgG

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation (By similarity). Induces susceptibility to atherosclerosis. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hm Mo

Pecam1, Pecam, Pecam-1, Platelet endothelial cell adhesion molecule, CD31

Mouse CD31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 511-540 amino acids from the C-terminal region of human Mouse CD31.

Hamster, mouse

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: Mouse CD31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 511-540 amino acids from the C-terminal region of human Mouse CD31. Specificity: Hamster, mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

4°C Do Not Freeze

DeLisser, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(43):18616-18621(2010) Zhang, C., et al. Dev. Dyn. 239(10):2594-2602(2010) Enciso, J.M., et al. Dev. Dyn. 239(10):2570-2583(2010) Ni, A., et al. Dev. Dyn. 239(9):2354-2366(2010) Sessa, A., et al. Genes Dev. 24(16):1816-1826(2010)

https://usbio-images.r.worldssl.net/prodimages/7/033493-AP_1.jpg