CD160, ID (CD160, BY55, CD160 antigen, Natural killer cell receptor BY55, CD160) (APC) | US Biological 033462-APC product information

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product summary

company name :

US Biological

product type :

antibody

product name :

CD160, ID (CD160, BY55, CD160 antigen, Natural killer cell receptor BY55, CD160) (APC)

catalog :

033462-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

033462-APC

Product wo Prefix :

CD160, ID (CD160, BY55, CD160 antigen, Natural killer cell receptor BY55, CD160) (APC)

Host :

rabbit

Product Type :

Pab

Conjugate :

APC

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

CD160 is an 27kD glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. Applications: Suitable for use in Western Blot, FLISA Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

CD160, BY55, CD160 antigen, Natural killer cell receptor BY55, CD160

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 56-82 in the central terminal region of human CD160, UniProt Accession #O95971.

Specificity :

Recognizes human CD160.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As Reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 56-82 in the central terminal region of human CD160, UniProt Accession #O95971. Specificity: Recognizes human CD160. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FL WB

Storage Temperature :

4°C Do Not Freeze

Reference :

1. Schmitt, C., et al. Genes Immun. 10(7):616-623(2009). 2. Kolz, M., et al. PLoS Genet. 5 (6), E1000504 (2009). 3. Giustiniani, J., et al. J. Immunol. 182(1):63-71(2009). 4. Cai, G., et al. Nat. Immunol. 9(2):176-185(2008)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/6/033462-APC_1.pdf