CCND1, CT (T288) (CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1, B Cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

CCND1, CT (T288) (CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1, B Cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene)

catalog :

033399

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

033399

Product wo Prefix :

CCND1, CT (T288) (CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1, B Cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1000 Western Blot: 1:100-500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1, B-cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene

Immunogen :

CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-295 amino acids from the C-terminal region of human CCND1.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-295 amino acids from the C-terminal region of human CCND1. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Aggarwal, P., et al., Cancer Cell 18(4): 329-340 (2010). 2. Iwatani, K., et al., Biochem. Biophys. Res. Commun. 400(3): 426-431 (2010). 3. Halilovic, E., et al., Cancer Res. 70(17): 6804-6814 (2010). 4. Zheng, W., et al., Anal. Quant. Cytol. Histol. 32(3): 155-160 (2010). 5. Satiroglu-Tufan, N.L., et al., Genet. Mol. Res. 9(3): 1557-1567 (2010).

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/34/033399_1.jpg