CCND1, CT (T288) (CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1, B Cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene) (APC) | US Biological 033399-APC product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

CCND1, CT (T288) (CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1, B Cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene) (APC)

catalog :

033399-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

033399-APC

Product wo Prefix :

CCND1, CT (T288) (CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1, B Cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene) (APC)

Host :

rabbit

Product Type :

Pab

Conjugate :

APC

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Applications: Suitable for use in Western Blot, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1, B-cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene

Immunogen :

CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-295 amino acids from the C-terminal region of human CCND1.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-295 amino acids from the C-terminal region of human CCND1. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FL WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Aggarwal, P., et al. Cancer Cell 18(4):329-340(2010) Iwatani, K., et al. Biochem. Biophys. Res. Commun. 400(3):426-431(2010) Halilovic, E., et al. Cancer Res. 70(17):6804-6814(2010) Zheng, W., et al. Anal. Quant. Cytol. Histol. 32(3):155-160(2010) Satiroglu-Tufan, N.L., et al. Genet. Mol. Res. 9(3):1557-1567(2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/9/033399-APC_1.jpg