CASP3, cleaved (Asp175) (CASP3, CPP32, Caspase-3, Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1, Caspase-3 subunit p17, Caspase-3 subunit p12)

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product summary

company name :

US Biological

product type :

antibody

product name :

CASP3, cleaved (Asp175) (CASP3, CPP32, Caspase-3, Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1, Caspase-3 subunit p17, Caspase-3 subunit p12)

catalog :

033203

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

033203

Product wo Prefix :

CASP3, cleaved (Asp175) (CASP3, CPP32, Caspase-3, Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1, Caspase-3 subunit p17, Caspase-3 subunit p12)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

CASP3 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Applications: Suitable for use in ELISA, Dot Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Dot Blot: 1:500 Immunohistochemistry (FFPE): 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

CASP3, CPP32, Caspase-3, Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1, Caspase-3 subunit p17, Caspase-3 subunit p12

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 149-175 of human cleaved-CASP3 (Asp175), UniProt Accession #P42574; P55213; Q95ND5. Species sequence homology: bovine, mouse, porcine, rat

Specificity :

Recognizes human cleaved-CASP3 (Asp175).

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 149-175 of human cleaved-CASP3 (Asp175), UniProt Accession #P42574; P55213; Q95ND5. Species sequence homology: bovine, mouse, porcine, rat Specificity: Recognizes human cleaved-CASP3 (Asp175). Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

DB E IHC

Storage Temperature :

-20°C

Reference :

1. Mei, Y., et al. Mol. Cell 37(5):668-678(2010) 2. Sohn, E.J., et al. Cancer Res. 70(3):1154-1163(2010) 3. Karamitopoulou, E., et al. Pathology 42(1):37-42(2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/49/033203_1.png