C2, NT (C2, Complement C2, C3/C5 convertase, Complement C2b fragment, Complement C2a fragment) (AP) | US Biological 032881-AP product information

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product summary

company name :

US Biological

product type :

antibody

product name :

C2, NT (C2, Complement C2, C3/C5 convertase, Complement C2b fragment, Complement C2a fragment) (AP)

catalog :

032881-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

human

product information

Catalog Number :

032881-AP

Product wo Prefix :

C2, NT (C2, Complement C2, C3/C5 convertase, Complement C2b fragment, Complement C2a fragment) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined. Applications: Suitable for use in Western Blot and ELISA. Other applications have not been tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Hm Hu

Alternate Name :

C2, Complement C2, C3/C5 convertase, Complement C2b fragment, Complement C2a fragment

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 147-176 in the N-terminal region of human C2, UniProt Accession #NP_000054; P06681.

Specificity :

Recognizes human C2. Species Crossreactivity: hamster

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As Reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 147-176 in the N-terminal region of human C2, UniProt Accession #NP_000054; P06681. Specificity: Recognizes human C2. Species Crossreactivity: hamster Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

4°C Do Not Freeze

Reference :

1. Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010) 2. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) 3. Liu, X., et al. Retina (Philadelphia, Pa.) 30(8):1177-1184(2010) 4. Han, S., et al. Hum. Immunol. 71(7):727-730(2010) 5. Ishii, Y., et al. J. Immunol. 151(1):170-174(1993)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/3/032881-AP_1.jpg