antibody

BMPR2, NT (Bone morphogenetic protein receptor type-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, PPH1) (APC)

032551-APC

200 ul

polyclonal

domestic rabbit

APC

BMPR2, NT (Bone morphogenetic protein receptor type-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, PPH1) (APC)

rabbit

Pab

APC

Antibodies

200 ul

IgG

BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension. Applications: Suitable for use in Immunohistochemistry, Flow Cytometry and FLISA. Other applications have not been tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu Mo

Bone morphogenetic protein receptor type-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, PPH1

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 27-56 in the N-terminal region of human BMPR2, UniProt Accession #Q13873.

Recognizes human BMPR2. Species Crossreactivity: mouse

Purified by Protein A/G affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by ammonium sulfate precipitation Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 27-56 in the N-terminal region of human BMPR2, UniProt Accession #Q13873. Specificity: Recognizes human BMPR2. Species Crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

FC FL IHC

4°C Do Not Freeze

1. Pouliot, F., et al., Cancer Res. 63(2):277-281 (2003). 2. Nishihara, A., et al., Mol. Biol. Cell 13 (9):3055-3063 (2002). 3. Humbert, M., et al., Eur Respir J 20(3):518-523 (2002). 4. Vitt, U.A., et al., Biol. Reprod. 67(2):473-480 (2002). 5. Nohe, A., et al., J. Biol. Chem. 277(7):5330-5338 (2002).

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