BMPR2, NT (BMPR2, PPH1, Bone morphogenetic protein receptor type-2, Bone morphogenetic protein receptor type II)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

BMPR2, NT (BMPR2, PPH1, Bone morphogenetic protein receptor type-2, Bone morphogenetic protein receptor type II)

catalog :

032550

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

032550

Product wo Prefix :

BMPR2, NT (BMPR2, PPH1, Bone morphogenetic protein receptor type-2, Bone morphogenetic protein receptor type II)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension. Applications: Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry and ELISA. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

BMPR2, PPH1, Bone morphogenetic protein receptor type-2, Bone morphogenetic protein receptor type II

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 28-59 in the N-terminal region of human BMPR2.

Specificity :

Recognizes human BMPR2.

Purity :

Purified by ammomnium sulfate precipitation.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As Reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by ammomnium sulfate precipitation. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 28-59 in the N-terminal region of human BMPR2. Specificity: Recognizes human BMPR2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E FC IHC WB

Storage Temperature :

-20°C

Reference :

1. Pouliot, F., et al., Cancer Res. 63(2):277-281 (2003). 2. Nishihara, A., et al., Mol. Biol. Cell 13(9):3055-3063 (2002). 3. Humbert, M., et al., Eur Respir J 20(3):518-523 (2002). 4. Vitt, U.A., et al., Biol. Reprod. 67(2):473-480 (2002). 5. Nohe, A., et al., J. Biol. Chem. 277(7):5330-5338 (2002).

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/15/032550_1.png

Picture4 Text :

Flow Cytometric analysis of HepG2 cells using 032550 (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.