Bim, BH3 Domain (BCL2L11, BIM, Bcl-2-like protein 11, Bcl2-interacting mediator of cell death) (AP) | US Biological 032519-AP product information

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product summary

company name :

US Biological

product type :

antibody

product name :

Bim, BH3 Domain (BCL2L11, BIM, Bcl-2-like protein 11, Bcl2-interacting mediator of cell death) (AP)

catalog :

032519-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

human

product information

Catalog Number :

032519-AP

Product wo Prefix :

Bim, BH3 Domain (BCL2L11, BIM, Bcl-2-like protein 11, Bcl2-interacting mediator of cell death) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

Bim belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bim contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:50-100 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

BCL2L11, BIM, Bcl-2-like protein 11, Bcl2-interacting mediator of cell death

Immunogen :

Bim BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide encoding the BH3 domain of human Bim.

Specificity :

Human

Purity :

Purified by Protein G affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein G affinity chromatography. Immunogen: Bim BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide encoding the BH3 domain of human Bim. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Chen, D., et al., Proc. Natl. Acad. Sci. U.S.A. 101(5):1235-1240 (2004). Luciano, F., et al., Oncogene 22(43):6785-6793 (2003). Sunters, A., et al., J. Biol. Chem. 278(50):49795-49805 (2003). Reginato, M.J., et al., Nat. Cell Biol. 5(8):733-740 (2003). Chen, D., et al., EMBO J. 21(24):6801-6810 (2002).

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/4/032519-AP_1.jpg