antibody

BCL2A1, BH3 Domain Specific (BCL2A1, BCL2L5, BFL1, GRS, HBPA1, Bcl-2-related protein A1, Bcl-2-like protein 5, Hemopoietic-specific early response protein, Protein BFL-1, Protein GRS)

032466

200 ul

polyclonal

domestic rabbit

nonconjugated

BCL2A1, BH3 Domain Specific (BCL2A1, BCL2L5, BFL1, GRS, HBPA1, Bcl-2-related protein A1, Bcl-2-like protein 5, Hemopoietic-specific early response protein, Protein BFL-1, Protein GRS)

rabbit

Pab

Antibodies

200 ul

IgG

Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

BCL2A1, BCL2L5, BFL1, GRS, HBPA1, Bcl-2-related protein A1, Bcl-2-like protein 5, Hemopoietic-specific early response protein, Protein BFL-1, Protein GRS

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 30-65 of human BCL2A1, BH3 Domain.

Recognizes human BCL2A1, BH3 Domain.

Purified by ammonium sulfate precipitation.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by ammonium sulfate precipitation. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 30-65 of human BCL2A1, BH3 Domain. Specificity: Recognizes human BCL2A1, BH3 Domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

-20°C

1. Akatsuka, Y., et al., J. Exp. Med. 197(11):1489-1500 (2003). 2. Edelstein, L.C., et al., Mol. Cell. Biol. 23(8):2749-2761 (2003). 3. Werner, A.B., et al., J. Biol. Chem. 77(25):22781-22788 (2002). 4. Akari, H., et al., J. Exp. Med. 194(9):1299-1311 (2001). 5. Harrington, J.J., et al., Nat. Biotechnol. 19(5):440-445 (2001).

https://usbio-images.r.worldssl.net/prodimages/2/032466_1.jpg