ATF3, CT (ATF3, Cyclic AMP-dependent transcription factor ATF-3, Activating transcription factor 3) (AP) | US Biological 032160-AP product information

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product summary

company name :

US Biological

product type :

antibody

product name :

ATF3, CT (ATF3, Cyclic AMP-dependent transcription factor ATF-3, Activating transcription factor 3) (AP)

catalog :

032160-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

human

product information

Catalog Number :

032160-AP

Product wo Prefix :

ATF3, CT (ATF3, Cyclic AMP-dependent transcription factor ATF-3, Activating transcription factor 3) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes. Applications: Suitable for use in Western Blot and ELISA. Other applications have not been tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

ATF3, Cyclic AMP-dependent transcription factor ATF-3, Activating transcription factor 3

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 140-168 in the C-terminal region of human ATF3. Species sequence homology: bovine, mouse, rat

Specificity :

Recognizes human ATF3.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 140-168 in the C-terminal region of human ATF3. Species sequence homology: bovine, mouse, rat Specificity: Recognizes human ATF3. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

4°C Do Not Freeze

Reference :

1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) 2. Lee, S.H., et al. Oncogene 29(37):5182-5192(2010) 3. Park, H.J., et al. Biochem. Biophys. Res. Commun. 400(1):72-77(2010) 4. Wu, X., et al. Nature 465(7296):368-372(2010) 5. Koh, I.U., et al. FEBS J. 277(10):2304-2317(2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/9/032160-AP_1.png