Androgen receptor, ID (AR, DHTR, NR3C4, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Androgen receptor, ID (AR, DHTR, NR3C4, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4)

catalog :

031869

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

031869

Product wo Prefix :

Androgen receptor, ID (AR, DHTR, NR3C4, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq]. Applications: Suitable for use in Western Blot. Other applications have not been tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

AR, DHTR, NR3C4, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4

Immunogen :

Synthetic peptide corresponding to 474-504 from the central region of human Androgen receptor, conjugated to KLH (P10275).

Specificity :

Recognizes human Androgen receptor.

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: Synthetic peptide corresponding to 474-504 from the central region of human Androgen receptor, conjugated to KLH (P10275). Specificity: Recognizes human Androgen receptor. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

1. Shu, S.K., et al. J. Biol. Chem. 285(43):33045-33053(2010) 2. Nedelsky, N.B., et al. Neuron 67(6):936-952(2010) 3. Panda, B., et al. Gynecol. Endocrinol. (2010) In press : 4. Schneider, G., et al. Am J Geriatr Psychiatry (2010) In press :5. Guadalupe-Grau, A., et al. PLoS ONE 5 (7), E11529 (2010) :

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/33/031869_1.jpg