Androgen receptor, ID (AR, DHTR, NR3C4, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) (APC) | US Biological 031869-APC product information

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product summary

company name :

US Biological

product type :

antibody

product name :

Androgen receptor, ID (AR, DHTR, NR3C4, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) (APC)

catalog :

031869-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

031869-APC

Product wo Prefix :

Androgen receptor, ID (AR, DHTR, NR3C4, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) (APC)

Host :

rabbit

Product Type :

Pab

Conjugate :

APC

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq]. Applications: Suitable for use in Western Blot, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

AR, DHTR, NR3C4, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4

Immunogen :

AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-504 amino acids from the Central region of human AR.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-504 amino acids from the Central region of human AR. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FL WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Shu, S.K., et al. J. Biol. Chem. 285(43):33045-33053(2010) Nedelsky, N.B., et al. Neuron 67(6):936-952(2010) Panda, B., et al. Gynecol. Endocrinol. (2010) In press : Schneider, G., et al. Am J Geriatr Psychiatry (2010) In press : Guadalupe-Grau, A., et al. PLoS ONE 5 (7), E11529 (2010) :

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/8/031869-APC_1.jpg