ANAPC5, ID (ANAPC5, APC5, Anaphase-promoting complex subunit 5, Cyclosome subunit 5) (APC) | US Biological 031867-APC product information

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product summary

company name :

US Biological

product type :

antibody

product name :

ANAPC5, ID (ANAPC5, APC5, Anaphase-promoting complex subunit 5, Cyclosome subunit 5) (APC)

catalog :

031867-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

031867-APC

Product wo Prefix :

ANAPC5, ID (ANAPC5, APC5, Anaphase-promoting complex subunit 5, Cyclosome subunit 5) (APC)

Host :

rabbit

Product Type :

Pab

Conjugate :

APC

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. Applications: Suitable for use in Western Blot, Flow Cytometry, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Flow Cytometry: 1:10-50 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

ANAPC5, APC5, Anaphase-promoting complex subunit 5, Cyclosome subunit 5

Immunogen :

ANAPC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the Central region of human ANAPC5.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: ANAPC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the Central region of human ANAPC5. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FC FL WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Wasch, R., et al. Oncogene 29(1):1-10(2010) Jin, L., et al. Cell 133(4):653-665(2008) Liu, J., et al. Cancer Biol. Ther. 5(7):760-762(2006) Dube, P., et al. Mol. Cell 20(6):867-879(2005) Turnell, A.S., et al. Nature 438(7068):690-695(2005)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/46/031867-APC_1.jpg