AKT1, phosphorylated (T450) (AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha) (AP) | US Biological 031755-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

AKT1, phosphorylated (T450) (AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha) (AP)

catalog :

031755-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

antigen modification :

phosphorylated

reactivity :

human

product information

Catalog Number :

031755-AP

Product wo Prefix :

AKT1, phosphorylated (T450) (AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Antigen Modification :

phosphorylated

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. Applications: Suitable for use in Dot Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Dot blot 1:100-500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha

Immunogen :

KLH-conjugated synthetic phosphopeptide mapping to a fragment of residues surrounding T450 of human AKT1, UniProt Accession #P31749. Species Sequence Homology: bovine, mouse and rat

Specificity :

Recognizes human AKT1.

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As Reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: KLH-conjugated synthetic phosphopeptide mapping to a fragment of residues surrounding T450 of human AKT1, UniProt Accession #P31749. Species Sequence Homology: bovine, mouse and rat Specificity: Recognizes human AKT1. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

DB E

Storage Temperature :

4°C Do Not Freeze

Reference :

1. Zhao, W.D., et al. Infect. Immun. 78(11):4809-4816(2010). 2. Sanematsu, F., et al. Circ. Res. 107(9):1102-1105(2010). 3. Nicodemus, K.K., et al. Arch. Gen. Psychiatry 67(10):991-1001(2010). 4. Treekitkarnmongkol, W., et al. World J. Gastroenterol. 16(32):4047-4054(2010). 5. Chen, J., et al. PLoS ONE 5 (8), E12293 (2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/5/031755-AP_1.jpg