antibody

TGFB2 (TGFB2, Transforming growth factor beta-2, BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, Polyergin) (AP)

031281-AP

200 ul

monoclonal

mouse

AP

220ct16.4.3.1

The same clone is also sold as:

• Invitrogen: MA5-37505
• Abnova: MAB12310

TGFB2 (TGFB2, Transforming growth factor beta-2, BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, Polyergin) (AP)

mouse

Mab

AP

Antibodies

200 ul

220ct16.4.3.1

IgG1,k

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested. Recommended Dilution: Immunohistochemistry: Formalin-fixed, paraffin-embedded sections Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

TGFB2, Transforming growth factor beta-2, BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, Polyergin

Recombinant protein corresponding to human TGFB2.

Recognizes human TGFB2.

Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Mab Isotype: IgG1,k Clone No: 220ct16.4.3.1 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein G affinity chromatography. Immunogen: Recombinant protein corresponding to human TGFB2. Specificity: Recognizes human TGFB2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

4°C Do Not Freeze

1. Nalpas, B., et al. Gut 59(8):1120-1126(2010) 2. Bailey, S.D., et al. Diabetes Care (2010) In press 3. Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) 4. Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) 5. Sambo, M.R., et al. PLoS ONE 5 (6), E11141 (2010)

https://usbio-images.r.worldssl.net/prodimages/26/031281-AP_1.png

Immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma using 031281 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of 031281 for immunohistochemistry.