antibody

Phosphatase, Alkaline, Placental, NT (PLAP, Alkaline Phosphatase Placental, Alkaline Phosphatase Placental Type, ALP, ALPP, Glycerophosphatase, PLAP-1, Regan Isozyme) (AP)

031194-AP

200 ul

monoclonal

mouse

AP

421CT8.1.1

The same clone is also sold as:

• OriGene: TA324348

Phosphatase, Alkaline, Placental, NT (PLAP, Alkaline Phosphatase Placental, Alkaline Phosphatase Placental Type, ALP, ALPP, Glycerophosphatase, PLAP-1, Regan Isozyme) (AP)

mouse

Mab

AP

Antibodies

200 ul

421CT8.1.1

IgG1

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. Applications: Suitable for use in Western Blot, ELISA. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100~500 Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C with the addition of glycerol. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Note: Applications are based on unconjugated antibody.

Hu

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 56-83 in the N-terminal region of human Phosphatase, Alkaline, Placental. UniProt Accession # P05187.

Recognizes human Phosphatase, Alkaline, Placental.

Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Mab Isotype: IgG1 Clone No: 421CT8.1.1 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein G affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 56-83 in the N-terminal region of human Phosphatase, Alkaline, Placental. UniProt Accession # P05187. Specificity: Recognizes human Phosphatase, Alkaline, Placental. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

4°C Do Not Freeze

1. Stec, B., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 8), 866-870 (2010) 2. Wang, F., et al. Am. J. Surg. Pathol. 33(10):1529-1539(2009) 3. Estrada, K., et al. Hum. Mol. Genet. 18(18):3516-3524(2009) 4. Zhu, J.F., et al. Zhonghua Wai Ke Za Zhi 47(5):381-384(2009) 5. Roberson, J.R., et al. Pediatr Blood Cancer 51(6):840-842(2008)

https://usbio-images.r.worldssl.net/prodimages/45/031194-AP_1.jpg