PARK8 (LRRK2) (LRRK2, PARK8, Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

PARK8 (LRRK2) (LRRK2, PARK8, Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin)

catalog :

031177

quantity :

200 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

133AT720

The same clone is also sold as:

OriGene: AM11057PU-N
Invitrogen: MA5-11155

reactivity :

human

product information

Catalog Number :

031177

Product wo Prefix :

PARK8 (LRRK2) (LRRK2, PARK8, Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

200 ul

Clone # USB :

133AT720

Isotype :

IgG1

Desc1 :

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. Applications: Suitable for use in Western Blot and ELISA. Other applications have not been tested. Recommended Dilution: Western Blot: 1:100-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo

Alternate Name :

LRRK2, PARK8, Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin

Immunogen :

Purified, His-tagged recombinant protein comprised of the C-terminal 261 residues of human LRRK2 (Q5S007).

Specificity :

Recognizes human LRRK2. Species crossreactivity: mouse

Purity :

Purified by Protein G affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 133AT720 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein G affinity chromatography. Immunogen: Purified, His-tagged recombinant protein comprised of the C-terminal 261 residues of human LRRK2 (Q5S007). Specificity: Recognizes human LRRK2. Species crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Olfactory heterogeneity in LRRK2 related Parkinsonism. Silveira-Moriyama L, et al. Mov Disord, 2010 Sep 3. PMID 20818658. 2. LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease. Saunders-Pullman R, et al. Mov Disord, 2010 Sep 3. PMID 20818610. 3. Low frequency of common LRRK2 mutations in Mexican patients with Parkinson's disease. Yescas P, et al. Neurosci Lett, 2010 Aug 18. PMID 20727385. 4. Absence of Commonly Reported Leucine-Rich Repeat Kinase 2 Mutations in Eastern Indian Parkinson's Disease Patients. Sanyal J, et al. Genet Test Mol Biomarkers, 2010 Aug 19. PMID 20722494. 5. Penetrance in Parkinson's disease related to the LRRK2 R1441G mutation in the Basque country (Spain). Ruiz-Mart√≠nez J, et al. Mov Disord, 2010 Aug 18. PMID 20721916.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/48/031177_1.jpg