antibody

MMP2 (MMP2, CLG4A, 72kD type IV collagenase, 72kD gelatinase, Gelatinase A, Matrix metalloproteinase-2, TBE-1, PEX)

031129

100 ul

monoclonal

mouse

nonconjugated

6E3F8

The same clone is also sold as:

• Abcam: ab264081, ab86607
• Abnova: MAB12299

MMP2 (MMP2, CLG4A, 72kD type IV collagenase, 72kD gelatinase, Gelatinase A, Matrix metalloproteinase-2, TBE-1, PEX)

mouse

Mab

Antibodies

100 ul

6E3F8

IgG2b,k

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:200-1000 Immunohistochemistry: 1:50~100 Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Hu

MMP2, CLG4A, 72kD type IV collagenase, 72kD gelatinase, Gelatinase A, Matrix metalloproteinase-2, TBE-1, PEX

MMP2 antibody is generated from mouse immunized with MMP2 recombinant protein.

Human

Ascites

Supplied as a liquid, crude ascites with 0.09% sodium azide.

As reported

Product Type: Mab Isotype: IgG2b,k Clone No: 6E3F8 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid, crude ascites with 0.09% sodium azide. Purity: Ascites Immunogen: MMP2 antibody is generated from mouse immunized with MMP2 recombinant protein. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

-20°C

Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas. Mossböck G, et al. Mol Vis, 2010 Aug 28. PMID 20808730. Clinical Impact of MMP and TIMP Gene Polymorphisms in Gastric Cancer. Alakus H, et al. World J Surg, 2010 Aug 21. PMID 20730428. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. Nikopensius T, et al. Birth Defects Res A Clin Mol Teratol, 2010 Jul 29. PMID 20672350. [Expressions of CD147, MMP-2 and MMP-9 in laryngeal carcinoma and clinical significance] Gou XX, et al. Zhonghua Yi Xue Za Zhi, 2010 May 11. PMID 20646600.

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