antibody

MMP14, CT (MMP14, Matrix metalloproteinase-14, MMP-X1, Membrane-type matrix metalloproteinase 1, Membrane-type-1 matrix metalloproteinase)

031128

100 ul

monoclonal

mouse

nonconjugated

133CT15.10.5.1

The same clone is also sold as:

• Abnova: MAB12762
• Invitrogen: MA5-37473

MMP14, CT (MMP14, Matrix metalloproteinase-14, MMP-X1, Membrane-type matrix metalloproteinase 1, Membrane-type-1 matrix metalloproteinase)

mouse

Mab

Antibodies

100 ul

133CT15.10.5.1

IgM

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. Applications: Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:1000~16000 Immunohistochemistry: 1:50~100 Flow Cytometry 1:10~50 Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Hu

MMP14, Matrix metalloproteinase-14, MMP-X1, Membrane-type matrix metalloproteinase 1, Membrane-type-1 matrix metalloproteinase

MMP14 antibody is generated from mouse immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MMP14.

Human

Ascites

Supplied as a liquid, crude ascites with 0.09% sodium azide.

As reported

Product Type: Mab Isotype: IgM Clone No: 133CT15.10.5.1 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid, crude ascites with 0.09% sodium azide. Purity: Ascites Immunogen: MMP14 antibody is generated from mouse immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MMP14. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E FC IHC WB

-20°C

A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624. Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen. Roghi C, et al. FEBS J, 2010 Aug. PMID 20608975.

https://usbio-images.r.worldssl.net/prodimages/29/031128_1.jpg