Interferon alpha (IFNa, IFN alpha, IFL, IFL Interferon, IFN Leukocyte, Interferon alpha 1, IFNa1, Interferon alpha 1/13, IFNa13, IFNAP22, Interferon alpha D, Interferon alpha Leukocyte, LeIF D, MGC138207, MGC138505, MGC138507) (AP) | US Biological 031057-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

Interferon alpha (IFNa, IFN alpha, IFL, IFL Interferon, IFN Leukocyte, Interferon alpha 1, IFNa1, Interferon alpha 1/13, IFNa13, IFNAP22, Interferon alpha D, Interferon alpha Leukocyte, LeIF D, MGC138207, MGC138505, MGC138507) (AP)

catalog :

031057-AP

quantity :

200 ul

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

278CT1

The same clone is also sold as:

Invitrogen: MA5-37518

reactivity :

human

product information

Catalog Number :

031057-AP

Product wo Prefix :

URL USB :

www.usbio.net/antibodies/031057-AP/Interferon-alpha-IFNa-IFN-alpha-IFL-IFL-Interferon-IFN-Leukocyte-Interferon-alpha-1-IFNa1-Interferon-alpha-113-IFNa13-IFNAP22-Interferon-alpha-D-Interferon-alpha-Leukocyte-LeIF-D-MGC138207-MGC138505-MGC138507-AP

Host :

mouse

Product Type :

Mab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Clone # USB :

278CT1

Isotype :

IgG1,k

Desc1 :

Interferons (IFNs) appear early after viral infection locally and systematically to limit spread of viral infection. They also affect cell differentiation, growth, surface antigen expression and immunoregulation. There are three naturally occurring interferons: alpha, beta and gamma. Interferon alpha (IFN-alpha, IFNa) is also known as leukocyte interferon. B-lymphocytes are the predominant cellular producers of INF-alpha. IFN-alpha is derived from lymphoblastic tissue. IFN-alpha comprises a family of related, homologous proteins, each exhibiting a unique activity profile. The activities of the different IFN-alpha species on viruses can vary twenty fold or more. INF-alpha has a number of therapeutic applications in the treatment of various human cancers and diseases of viral origin. Recombinant IFN-alphas from both natural and synthetic genes bind to a common cell surface receptor and induce anti-viral activity in a variety of cell lines. When binding to discrete cell surface receptors on target cells, IFN-alpha induces rapid changes in Jak/Stat phosphorylation, which intiates the Jak/Stat signaling pathway. IFN-alpha signaling also involves production of DAG without an increased intracellular free calcium concentration and the subsequent activation of calcium-independent isoforms of PKC (beta and epsilon). All IFN-alpha signaling pathways lead to final alterations of gene expression, which mediate their pleiotropic biologic activities. IFN-alpha remains the most frequently used IFN for both research and clinical applications. It was first approved for combating malignancies. Anti-viral applications such as chronic Hepatitis B and C now make up the bulk of IFN sales. Different countries throughout the world have approved Hu-IFNa for different applications include: Chronic Hepatitis B, Chronic Hepatitis C, Hairy Cell Leukemia, Kaposi's Sarcoma (AIDS-related), Cutaneous T-cell Leukemia, Chronic Myeloid Leukemia, Renal Cell Carcinoma, Non-Hodgkin's Lymphoma, Adjuvant Therapy for Malignant Melanoma, Bladder Cell Carcinoma, Colon Carcinoma, Laryngeal Papillomatosis, Cervical Dysplasia, Condylomata Acuminata (Venereal Warts), Multiple Myeloma. Applications:. Suitable for use in Western Blot, ELISA. Recommended Dilution:. ELISA: 1:1000. Western Blot: 1:100. Storage and Stability:. May be stored at 4 C for short-term only. For long-term storage, store at -20 C with the addition of glycerol. Aliquots are stable for at least 6 months at -20 C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Immunogen :

Interferon-alpha Mab is generated from mouse immunized with Interferon-alpha recombinant protein.

Specificity :

Human

Purity :

Purified by Protein G affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Mab. Isotype: IgG1,k. Clone No: 278CT1. Host: mouse. Source: human. Concentration: As reported. Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein G affinity chromatography. Immunogen: Interferon-alpha Mab is generated from mouse immunized with Interferon-alpha recombinant protein. Specificity: Human. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

4 C Do Not Freeze

Picture 1 File Name :

usbio-images.r.worldssl.net/prodimages/39/031057-AP_1.jpg