HLA-B (HLA-B, HLAB, HLA class I histocompatibility antigen, B-27 alpha chain, MHC class I antigen B*27)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

HLA-B (HLA-B, HLAB, HLA class I histocompatibility antigen, B-27 alpha chain, MHC class I antigen B*27)

catalog :

031023

quantity :

200 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

528CT10.4.1

reactivity :

human

product information

Catalog Number :

031023

Product wo Prefix :

HLA-B (HLA-B, HLAB, HLA class I histocompatibility antigen, B-27 alpha chain, MHC class I antigen B*27)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

200 ul

Clone # USB :

528CT10.4.1

Isotype :

IgM

Desc1 :

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. Applications: Suitable for use in Western Blot, ELISA. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100~250 Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Calc Crossreactivity :

Alternate Name :

HLA-B, HLAB, HLA class I histocompatibility antigen, B-27 alpha chain, MHC class I antigen B*27

Immunogen :

HLA-B Mab is generated from mice immunized with a KLH conjugated synthetic peptide selected from human HLA-B.

Specificity :

Human

Purity :

Purified by ammonium sulfate precipitation.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Mab Isotype: IgM Clone No: 528CT10.4.1 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide. Purity: Purified by ammonium sulfate precipitation. Immunogen: HLA-B Mab is generated from mice immunized with a KLH conjugated synthetic peptide selected from human HLA-B. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

Parsons, M.S., et al. J. Infect. Dis. 202 SUPPL 3, S356-S360 (2010) Brockman, M.A., et al. J. Virol. 84(22):11937-11949(2010) Noble, J.A., et al. Diabetes 59(11):2972-2979(2010) Lipponen, K., et al. Diabetes (2010) In press Liao, Y.Q., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18(4):1055-1058(2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/45/031023_1.jpg