antibody

HLA-A (HLA-A, HLAA, HLA class I histocompatibility antigen, A-3 alpha chain, MHC class I antigen A*3)

031021

100 ul

monoclonal

mouse

nonconjugated

7G7F9

The same clone is also sold as:

• Invitrogen: MA5-37475

HLA-A (HLA-A, HLAA, HLA class I histocompatibility antigen, A-3 alpha chain, MHC class I antigen A*3)

mouse

Mab

Antibodies

100 ul

7G7F9

IgG1,k

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. Applications: Suitable for use in Western Blot, ELISA. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:500-1000 Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Hu

HLA-A, HLAA, HLA class I histocompatibility antigen, A-3 alpha chain, MHC class I antigen A*3

HLA-A antibody is generated from mouse immunized with a KLH conjugated synthetic peptide selected from the Center region of human HLA-A.

Human

Ascites

Supplied as a liquid, crude ascites with 0.09% sodium azide.

As reported

Product Type: Mab Isotype: IgG1,k Clone No: 7G7F9 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid, crude ascites with 0.09% sodium azide. Purity: Ascites Immunogen: HLA-A antibody is generated from mouse immunized with a KLH conjugated synthetic peptide selected from the Center region of human HLA-A. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

-20°C

HLA Class I and Genetic Susceptibility to Type 1 Diabetes: Results from the Type 1 Diabetes Genetics Consortium. Noble JA, et al. Diabetes, 2010 Aug 26. PMID 20798335. Effect of HLA Class I and Class II Alleles on Progression from Autoantibody Positivity to Overt Type 1 Diabetes in Children with Risk-Associated Class II Genotypes. Lipponen K, et al. Diabetes, 2010 Aug 25. PMID 20739684. Infectious mononucleosis-linked HLA class I single nucleotide polymorphism is associated with multiple sclerosis. Jafari N, et al. Mult Scler, 2010 Aug 24. PMID 20736246. [Associations of Human Leukocyte Antigen-A, B, DRB1 Genes with Leukemia Patients in Anhui Province of China.] Liao YQ, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2010 Jul. PMID 20723328. Longer survival associated with HLA-A*03, B*14 among 212 hemochromatosis probands with HFE C282Y homozygosity and HLA-A and -B typing and haplotyping. Barton JC, et al. Eur J Haematol, 2010 Aug 14. PMID 20722701.

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