GAD2 (GAD2, GAD65, Glutamate decarboxylase 2, 65kD glutamic acid decarboxylase, Glutamate decarboxylase 65kD isoform)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

GAD2 (GAD2, GAD65, Glutamate decarboxylase 2, 65kD glutamic acid decarboxylase, Glutamate decarboxylase 65kD isoform)

catalog :

030979

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

458CT17.2.4

reactivity :

human

product information

Catalog Number :

030979

Product wo Prefix :

GAD2 (GAD2, GAD65, Glutamate decarboxylase 2, 65kD glutamic acid decarboxylase, Glutamate decarboxylase 65kD isoform)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

458CT17.2.4

Isotype :

IgG1

Desc1 :

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. Applications: Suitable for use in Western Blot and ELISA. Other applications not tested. Recommended Dilutions: Western Blot: 1:100-1:1600 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Rt

Alternate Name :

GAD2, GAD65, Glutamate decarboxylase 2, 65kD glutamic acid decarboxylase, Glutamate decarboxylase 65kD isoform

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 109-138 of human GAD2. Species Sequence Homology: mouse and porcine

Specificity :

Recognizes human GAD2. Species Crossreactivity: rat

Purity :

Ascites

Form :

Supplied as a liquid, 0.09% sodium azide

Concentration :

Not Determined

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 458CT17.2.4 Host: mouse Source: human Concentration: Not Determined Form: Supplied as a liquid, 0.09% sodium azide Purity: Ascites Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 109-138 of human GAD2. Species Sequence Homology: mouse and porcine Specificity: Recognizes human GAD2. Species Crossreactivity: rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). 2. Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010). 3. Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010). 4. Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010). 5. Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/39/030979_1.pdf