ESR1/ER (ESR1, ESR, NR3A1, Estrogen receptor, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1)

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product summary

company name :

US Biological

product type :

antibody

product name :

ESR1/ER (ESR1, ESR, NR3A1, Estrogen receptor, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1)

catalog :

030951

quantity :

200 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

415CT16.3.2.1

reactivity :

human

product information

Catalog Number :

030951

Product wo Prefix :

ESR1/ER (ESR1, ESR, NR3A1, Estrogen receptor, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

200 ul

Clone # USB :

415CT16.3.2.1

Isotype :

IgG1

Desc1 :

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. Applications: Suitable for use in Western Blot. Other applications have not been tested. Recommended Dilution: Western Blot: 1:100-1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

ESR1, ESR, NR3A1, Estrogen receptor, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1

Immunogen :

Synthetic peptide corresponding to a portion of amino acids within aa246-273 from human ESR1 protein, conjugated to KLH (NP_005294.1). Species sequence homology: bovine, mouse, porcine, rat

Specificity :

Recognized human ESR1 at ~31kD.

Purity :

Purified by Protein G affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 415CT16.3.2.1 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein G affinity chromatography. Immunogen: Synthetic peptide corresponding to a portion of amino acids within aa246-273 from human ESR1 protein, conjugated to KLH (NP_005294.1). Species sequence homology: bovine, mouse, porcine, rat Specificity: Recognized human ESR1 at ~31kD. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

Geradts, J., et al. Cancer Invest. 28(9):969-977(2010) Hayes, D.F., et al. Clin. Pharmacol. Ther. 88(5):626-629(2010) Lupien, M., et al. Genes Dev. 24(19):2219-2227(2010) Corbo, R.M., et al. J. Gerontol. A Biol. Sci. Med. Sci. (2010) In press Kim, S., et al. Fertil. Steril. (2010) In press

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/31/030951_1.jpg