BAX (BAX, BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4) | US Biological 030801 product information

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product summary

company name :

US Biological

product type :

antibody

product name :

BAX (BAX, BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4)

catalog :

030801

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

557CT5.2.1

reactivity :

human

product information

Catalog Number :

030801

Product wo Prefix :

BAX (BAX, BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

557CT5.2.1

Isotype :

IgG2b

Desc1 :

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. Applications: Suitable for use in Western Blot, ELISA. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:500~8000 Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Calc Crossreactivity :

Alternate Name :

BAX, BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4

Immunogen :

Purified His-tagged BAX protein (fragment).

Specificity :

Human

Purity :

Ascites

Form :

Supplied as a liquid, crude ascites with 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Mab Isotype: IgG2b Clone No: 557CT5.2.1 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid, crude ascites with 0.09% sodium azide. Purity: Ascites Immunogen: Purified His-tagged BAX protein (fragment). Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Montessuit, S., et al. Cell 142(6):889-901(2010) Ding, J., et al. J. Biol. Chem. 285(37):28749-28763(2010) Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press Yu, D.K., et al. Zhonghua Zhong Liu Za Zhi 32(5):324-327(2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/2/030801_1.jpg