antibody

ANPEP/CD13 (ANPEP, APN, CD13, PEPN, Aminopeptidase N, Alanyl aminopeptidase, Aminopeptidase M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, CD_antigen=CD13) (AP)

030775-AP

200 ul

monoclonal

mouse

AP

505CT12.1.2

ANPEP/CD13 (ANPEP, APN, CD13, PEPN, Aminopeptidase N, Alanyl aminopeptidase, Aminopeptidase M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, CD_antigen=CD13) (AP)

mouse

Mab

AP

Antibodies

200 ul

505CT12.1.2

IgG2a

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Applications: Suitable for use in Western Blot and ELISA. Other applications have not been tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

ANPEP, APN, CD13, PEPN, Aminopeptidase N, Alanyl aminopeptidase, Aminopeptidase M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, CD_antigen=CD13

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 156-184 of human ANPEP/CD13.

Recognizes human ANPEP/CD13.

Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Mab Isotype: IgG2a Clone No: 505CT12.1.2 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein G affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 156-184 of human ANPEP/CD13. Specificity: Recognizes human ANPEP/CD13. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

4°C Do Not Freeze

1. Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) 2. Curnis, F., et al. J. Biol. Chem. 285(12):9114-9123(2010) 3. Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) 4. Ito, S., et al. Gen Thorac Cardiovasc Surg 57(11):591-598(2009) 5. Ju, S., et al. Cell Cycle 8(16):2578-2585(2009)

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