antibody

ANPEP (ANPEP, APN, CD13, PEPN, Aminopeptidase N, Alanyl aminopeptidase, Aminopeptidase M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, CD_antigen=CD13) (Biotin)

030773-Biotin

200 ul

monoclonal

mouse

biotin

496CT9.1.1

ANPEP (ANPEP, APN, CD13, PEPN, Aminopeptidase N, Alanyl aminopeptidase, Aminopeptidase M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, CD_antigen=CD13) (Biotin)

mouse

Mab

Biotin

Antibodies

200 ul

496CT9.1.1

IgG1

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Applications: Suitable for use in Western Blot, ELISA. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100~500 Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

ANPEP, APN, CD13, PEPN, Aminopeptidase N, Alanyl aminopeptidase, Aminopeptidase M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, CD_antigen=CD13

Purified His-tagged ANPEP protein (fragment).

Human

Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

As reported

Product Type: Mab Isotype: IgG1 Clone No: 496CT9.1.1 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin. Purity: Purified by Protein G affinity chromatography. Immunogen: Purified His-tagged ANPEP protein (fragment). Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

-20°C

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) Curnis, F., et al. J. Biol. Chem. 285(12):9114-9123(2010) Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) Ito, S., et al. Gen Thorac Cardiovasc Surg 57(11):591-598(2009) Ju, S., et al. Cell Cycle 8(16):2578-2585(2009)

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