TNF-alpha (Tumor necrosis factor) | US Biological 030690 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

TNF-alpha (Tumor necrosis factor)

catalog :

030690

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13B768

reactivity :

human

product information

Catalog Number :

030690

Product wo Prefix :

TNF-alpha (Tumor necrosis factor)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

13B768

Isotype :

IgG1

Desc1 :

TNF-alpha (tumor necrosis factor alpha) is an important cytokine produced by numerous cell types including neutrophils, activated lymphocytes, macrophages and NK cells. It plays a critical role in inflammatory responses and in apoptosis. TNF-alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF-alpha exists as a multimer of two, three, or five non covalently linked units, but shows a single 17kD band following SDS PAGE under non reducing conditions. Although it has little effect on many cultured normal human cells, TNF-alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF-alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF-alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex. Applications: Western Bloting: 1:500-1:2000. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

DIF; TNFA; TNFSF2; TNF-alpha

Immunogen :

Recombinant protein corresponding to human TNF-alpha.

Specificity :

Recognizes human TNF-alpha.

Purity :

Ascites

Form :

Supplied as a liquid in 0.03% sodium azide.

Concentration :

Not determined

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B768 Host: mouse Source: human Concentration: Not determined Form: Supplied as a liquid in 0.03% sodium azide. Purity: Ascites Immunogen: Recombinant protein corresponding to human TNF-alpha. Specificity: Recognizes human TNF-alpha. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Knowlton KU. Yajima T. J Am Coll Cardiol. 2004,Sep 15, 44(6):1298-300. 2. Reynolds JL. Ignatowski TA. Gallant S.et al. Brain Res. 2004,Oct 8, 1023(1):112-20. 3. Dulak J. Tomala K. Loboda A. et al. Life Sci. 2004,Oct 8, 75(21):2573-86.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/33/030690_1.jpg