RB (retinoblastoma 1, Retinoblastoma-associated protein) | US Biological 030594 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

RB (retinoblastoma 1, Retinoblastoma-associated protein)

catalog :

030594

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13B672

reactivity :

human

product information

Catalog Number :

030594

Product wo Prefix :

RB (retinoblastoma 1, Retinoblastoma-associated protein)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

13B672

Isotype :

IgG1

Desc1 :

The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene (Rb). Applications: Suitable for use in ELISA ans Immunohistochemistry. Other applications not tested. Recommended Dilutions: ELISA: 1:10,000 Immunohistochemistry: 1:200-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

RB; pRb; OSRC; pp110; p105-Rb; RB1

Immunogen :

Purified recombinant fragment of human RB expressed in E. coli.

Specificity :

Recognizes human RB.

Purity :

Ascites

Form :

Supplied as a liquid, 0.03% sodium azide

Concentration :

Not Determined

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B672 Host: mouse Source: human Concentration: Not Determined Form: Supplied as a liquid, 0.03% sodium azide Purity: Ascites Immunogen: Purified recombinant fragment of human RB expressed in E. coli. Specificity: Recognizes human RB. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC

Storage Temperature :

-20°C

Reference :

1. Oncogene 19: 562-570. 2. Cell 81: 323-330.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/3/030594_1.jpg