PTEN Tumor Suppressor Protein (PTEN, MMAC1, Phosphatase and Tensin Homolog, TEP1)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

PTEN Tumor Suppressor Protein (PTEN, MMAC1, Phosphatase and Tensin Homolog, TEP1)

catalog :

030575

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13B653

reactivity :

human

product information

Catalog Number :

030575

Product wo Prefix :

PTEN Tumor Suppressor Protein (PTEN, MMAC1, Phosphatase and Tensin Homolog, TEP1)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

13B653

Isotype :

IgG1

Desc1 :

PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. Applications: Suitable for use in ELISA, Flow Cytometry, Immunocytochemistry/Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:10,000 Flow cytometry: 1:200-1:400 mmunocytochemistry/Immunofluorescence: 1:200-1:1,000 Western Blot: 1:500-1:2,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo

Alternate Name :

BZS; MHAM; TEP1; PTEN1

Immunogen :

Purified recombinant fragment of PTEN expressed in E. coli.

Specificity :

Human, Mouse

Purity :

Purified by Protein G affinity chromatography.

Form :

Supplied as a liquid in PBS, 0.03% sodium azide, 50% glycerol.

Concentration :

~1mg/ml

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B653 Host: mouse Source: human Concentration: ~1mg/ml Form: Supplied as a liquid in PBS, 0.03% sodium azide, 50% glycerol. Purity: Purified by Protein G affinity chromatography. Immunogen: Purified recombinant fragment of PTEN expressed in E. coli. Specificity: Human, Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E FC IC IF WB

Storage Temperature :

-20°C

Reference :

1. Nat Genet. 1998 Aug;19(4):348-55. 2. Oncogene. 1999 May 20;18(20):3181-5. 3. Eur J Immunol. 2002 Apr;32(4):1196-204.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/49/030575_1.jpg