PPM1A | US Biological 030557 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

PPM1A

catalog :

030557

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13B635

reactivity :

human

product information

Catalog Number :

030557

Product wo Prefix :

PPM1A

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

13B635

Isotype :

IgG1

Desc1 :

The protein encoded by this gene is a member of the PP2C family of Ser:Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53:p53, which leads to G2:M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. Applications: Western Blot: 1:500-1:2000 Flow Cytometry: 1:200-1:400 ELISA: 1:10000 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mk

Alternate Name :

PP2CA; PP2Calpha; PP2C-ALPHA

Immunogen :

Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. coli.

Specificity :

Human, Monkey

Purity :

Purified

Form :

Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer.

Concentration :

~1mg/ml

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B635 Host: mouse Source: human Concentration: ~1mg/ml Form: Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer. Purity: Purified Immunogen: Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. coli. Specificity: Human, Monkey Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E FC WB

Storage Temperature :

-20°C

Reference :

1.Biol Psychiatry. 2011 Feb 15;69(4):360-5. 2.Cell Signal. 2009 Jan;21(1):95-102.