p16 (ARF, CDK4I, CDKN2, CMM2, Cyclin-dependent kinase 4 inhibitor A, Cyclin-dependent kinase inhibitor 2A, isoform 4, INK4A)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

p16 (ARF, CDK4I, CDKN2, CMM2, Cyclin-dependent kinase 4 inhibitor A, Cyclin-dependent kinase inhibitor 2A, isoform 4, INK4A)

catalog :

030518

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13B596

reactivity :

human

product information

Catalog Number :

030518

Product wo Prefix :

p16 (ARF, CDK4I, CDKN2, CMM2, Cyclin-dependent kinase 4 inhibitor A, Cyclin-dependent kinase inhibitor 2A, isoform 4, INK4A)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

13B596

Isotype :

IgG1

Desc1 :

p16 (cyclin-dependent kinase inhibitor 2A, INK4a) is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 / Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16 INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia. Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:500-1:2000 Immunohistochemistry: 1:200-1:1000 ELISA: 1:10,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Immunogen :

Purified recombinant fragment of P16 expressed in E. coli.

Specificity :

Recognizes human p16.

Purity :

Purified

Form :

Supplied as a liquid in PBS, 0.03% sodium azide.

Concentration :

~1mg/ml

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B596 Host: mouse Source: human Concentration: Not Determined Form: Supplied as a liquid in PBS, 0.03% sodium azide. Purity: Purified Immunogen: Purified recombinant fragment of P16 expressed in E. coli. Specificity: Recognizes human p16. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

-20°C

Reference :

1. Bai, F. et al. Mol. Cell. Biol.2003 23, 1269-1277. 2. Lowe, S.W. and Sherr, C.J. Curr. Opin. Genet.2003 Dev.13, 77-83. 3. Sherr, C.J. Nat. Rev. Mol. Cell Biol.2001 2, 731-737