MAP2K2 (MAPK/ERK kinase 2, MAP kinase kinase 2, MAPKK2, MAPKK 2, MEK2)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

MAP2K2 (MAPK/ERK kinase 2, MAP kinase kinase 2, MAPKK2, MAPKK 2, MEK2)

catalog :

030415

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13B493

reactivity :

human

product information

Catalog Number :

030415

Product wo Prefix :

MAP2K2 (MAPK/ERK kinase 2, MAP kinase kinase 2, MAPKK2, MAPKK 2, MEK2)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

13B493

Isotype :

IgG1

Desc1 :

MAP2K2, also called MEK2, it is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. Applications: Western Bloting: 1:500-1:2000. Immunofluorescence: 1:200-1:1000. Flow cytometry: 1:200-1:400. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo Rt

Alternate Name :

MEK2; MKK2; MAPKK2

Immunogen :

Purified recombinant fragment of human MAP2K2 expressed in E. coli.

Specificity :

Human, Mouse, Rat

Purity :

Ascites

Form :

Ascites fluid, 0.03% sodium azide.

Concentration :

Not determined

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B493 Host: mouse Source: human Concentration: Not determined Form: Ascites fluid, 0.03% sodium azide. Purity: Ascites Immunogen: Purified recombinant fragment of human MAP2K2 expressed in E. coli. Specificity: Human, Mouse, Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E FC WB

Storage Temperature :

-20°C

Reference :

1. Mol Cell Biol. 1993 Aug;13(8):4679-90. 2. Eur J Biochem. 1995 Nov 15;234(1):32-8. 3. Oncogene. 1998 Jul 9;17(1):57-65.