KSHV ORF45 (Virion phosphoprotein) | US Biological 030389 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

KSHV ORF45 (Virion phosphoprotein)

catalog :

030389

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13B467

reactivity :

Human gammaherpesvirus 8

product information

Catalog Number :

030389

Product wo Prefix :

KSHV ORF45 (Virion phosphoprotein)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

13B467

Isotype :

IgG1

Desc1 :

Kaposi's sarcoma-associated Herpes virus (KSHV) belongs to the gamma-(2)-Herpes virus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions Applications: Western Bloting: 1:500-1:2000. Immunofluorescence: 1:200-1:1000. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Alternate Name :

ORF45

Immunogen :

Purified recombinant fragment of KSHV ORF45 expressed in E. coli.

Specificity :

KSHV

Purity :

Ascites

Form :

Ascites fluid, 0.03% sodium azide.

Concentration :

Not determined

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B467 Host: mouse Concentration: Not determined Form: Ascites fluid, 0.03% sodium azide. Purity: Ascites Immunogen: Purified recombinant fragment of KSHV ORF45 expressed in E. coli. Specificity: KSHV Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Chang Y. et al. 1994. Science. 266:1865-1869. 2. Zhu FX. et al. 2002. PNAS. 99: 5573-5578. 3. Zhu FX. et al. J Virol. 2003. April (77): 4221-4230.