GCK (Glucokinase) | US Biological 030265 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

GCK (Glucokinase)

catalog :

030265

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13B343

reactivity :

human

product information

Catalog Number :

030265

Product wo Prefix :

GCK (Glucokinase)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

13B343

Isotype :

IgG1

Desc1 :

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). Applications: Western Bloting: 1:500-1:2000. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3

Immunogen :

Purified recombinant fragment corresponding to aa1-198 of human GCK expressed in E. coli.

Specificity :

Recognizes human GCK.

Purity :

Ascites

Form :

Supplied as a liquid, 0.03% sodium azide.

Concentration :

Not Determined

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B343 Host: mouse Source: human Concentration: Not Determined Form: Supplied as a liquid, 0.03% sodium azide. Purity: Ascites Immunogen: Purified recombinant fragment corresponding to aa1-198 of human GCK expressed in E. coli. Specificity: Recognizes human GCK. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Mol Endocrinol. 2009 Dec; 23(12):1983-9. 2. Int J Mol Med. 2009 Aug; 24(2):233-46.