FAS (TNF receptor superfamily, member 6) | US Biological 030213 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

FAS (TNF receptor superfamily, member 6)

catalog :

030213

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13B291

reactivity :

human

product information

Catalog Number :

030213

Product wo Prefix :

FAS (TNF receptor superfamily, member 6)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

13B291

Isotype :

IgG1

Desc1 :

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. Applications: Western Bloting: 1:500-1:2000. Immunofluorescence: 1:200-1:1000. Flow cytometry: 1:200-1:400. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6

Immunogen :

Purified recombinant fragment of human FAS expressed in E. coli.

Specificity :

human

Purity :

Purified

Form :

Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer.

Concentration :

~1mg/ml

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B291 Host: mouse Source: human Concentration: ~1mg/ml Form: Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer. Purity: Purified Immunogen: Purified recombinant fragment of human FAS expressed in E. coli. Specificity: human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E FC WB

Storage Temperature :

-20°C

Reference :

Am J Hum Genet. 2009 Nov;85(5):628-42 Int J Surg Pathol. 2010 Dec;18(6):493-8