DAXX (BING2, DAP6, Daxx, Death domain-associated protein 6, EAP1, ETS1-associated protein 1, Fas death domain-associated protein)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

DAXX (BING2, DAP6, Daxx, Death domain-associated protein 6, EAP1, ETS1-associated protein 1, Fas death domain-associated protein)

catalog :

030139

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13B217

reactivity :

human

product information

Catalog Number :

030139

Product wo Prefix :

DAXX (BING2, DAP6, Daxx, Death domain-associated protein 6, EAP1, ETS1-associated protein 1, Fas death domain-associated protein)

Host :

mouse

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

13B217

Isotype :

IgG1

Desc1 :

DAXX (death-domain associated protein), it is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. Applications: Western Bloting: 1:500-1:2000. Immunofluorescence: 1:200-1:1000. Flow cytometry: 1:200-1:400. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

DAP6; EAP1; BING2

Immunogen :

Purified recombinant fragment of human DAXX expressed in E. coli.

Specificity :

Human

Purity :

Purified by Protein G affinity chromatography.

Form :

Supplied as a liquid in PBS, 0.03% sodium azide, 50% glycerol.

Concentration :

~1mg/ml

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B217 Host: mouse Source: human Concentration: ~1mg/ml Form: Supplied as a liquid in PBS, 0.03% sodium azide, 50% glycerol. Purity: Purified by Protein G affinity chromatography. Immunogen: Purified recombinant fragment of human DAXX expressed in E. coli. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E FC WB

Storage Temperature :

-20°C

Reference :

1. Cell. 1997 Jun 27;89(7):1067-76. 2. Biochem Biophys Res Commun. 2000 Dec 9;279(1):6-10. 3. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5.