MAP2 (Microtubule-associated Protein 2, MAP-2) (Cy3) discontinued

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

MAP2 (Microtubule-associated Protein 2, MAP-2) (Cy3) discontinued

catalog :

029534

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

Cy3

clone name :

13A207

reactivity :

bovine

product information

Catalog Number :

029534

Product wo Prefix :

MAP2 (Microtubule-associated Protein 2, MAP-2) (Cy3) discontinued

Host :

mouse

Product Type :

Mab

Conjugate :

Cy3

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

13A207

Isotype :

IgG1

Desc1 :

The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin, stabilizes microtubules and is an excellent marker for neurons. MAP-2 is essential for the development and maintenance of neuronal morphology. Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation. All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31aa motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules. Applications: Suitable for use in Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunocytochemistry: 1:100 Optimal dilutions to be determined by the researcher. Positive Control: Rat E18 primary cortex cells Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Cy conjugates are sensitive to light.

Calc Crossreactivity :

Hu Rt

Immunogen :

Bovine brain microtubule protein. Species sequence homology: Bovine, chicken, human, and mouse (100%).

Specificity :

Recognizes rat MAP2.

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, 15mg/ml BSA, 0.09% sodium azide. Labeled with Cy3.

Concentration :

Not determined

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13A207 Host: mouse Source: human Concentration: Not determined Form: Supplied as a liquid in PBS, 15mg/ml BSA, 0.09% sodium azide. Labeled with Cy3. Purity: Purified by Protein A affinity chromatography. Immunogen: Bovine brain microtubule protein. Species sequence homology: Bovine, chicken, human, and mouse (100%). Specificity: Recognizes rat MAP2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

1. Matsuda, K., et al. (2006). J Biol Chem. 281: 25577-25587. 2. Yasuhara, T., et al. (2006). J. Neurosci. 26: 12497-12511. 3. Sigurjonsson, O., et al. (2005). Proc Natl Acad Sci USA. 102:5227-5232. 4. Tan, P., et al. (2007). Proc. Natl. Acad. Sci. USA. 104:17524-17529. 5. Huang, C., et al. (2008). J Neurosci Res. 86(6):1277-1289.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/48/029534_1.jpg