Toronto BioScience

protein

Recombinant Human Retinol Binding Protein 4

41060

0.1 mg

194 USD

41060

Recombinant Human Retinol Binding Protein 4

E.Coli

Recombinant Protein

0.1 mg

194 USD

Type: Recombinant. Tag: His. Source: E.Coli. Total 211 AA. Mw: 24.4 kDa (calculated). N-terminal His-tag and TEV cleavage site, 28 extra AA (highlighted).

Human specificity

Retinol binding protein 4(RBP4), originally known as a specific transport of retinol in blood, is also a novel inflammatory and insulin resistance marker. Serum levels of RBP4 increased in insulin resistant and diabetes. Studies both in human and animal suggested that serum levels of RBP4 plays a key role in the link between obesity, insulin resistant and diabetes. Animal experiments found that increased secretion of RBP4 might reduces insulin-dependent glucose uptake by muscle tissue by reducing the activity of PI(3)K (phosphoinositide 3-kinase), and increased hepatic glucose output by increasing the expression of the enzyme PEPCK. However, whether serum RBP4 could be a biomarker of type 2 diabetes risk still remain unclear.

RBP4

Human

>95%

ELISA and Western blotting.

Store lyophilized protein at –20°C. Aliquot reconstituted protein and store at –80°C. Avoid repeated freezing /thawing cycles.